Spironolactone for Pulmonary Arterial Hypertension. Pulmonary hypertension occurs when the pressure in the blood vessels that carry blood from your heart to your lungs is higher than normal. Living at a high altitude; Use of certain weight-loss drugs; Use of illegal drugs such as cocaine; Use of selective serotonin reuptake inhibitors (SSRIs), used to treat depression and anxiety ; Complications. This study is located at multiple sites across the United States and Canada, including California, Colorado, Massachusetts, New York, Pennsylvania, Tennessee, and Alberta, Canada. This study is located in Pittsburgh, Pennsylvania. Avoid high altitudes when possible and discuss with your doctor any plans for air travel or visits to places at high altitude. In the United States, the most common cause of pulmonary hypertension is left heart disease. These symptoms may get worse over time and could eventually lead to serious complications such as right heart failure. Many medical conditions can cause pulmonary hypertension. This study is located in Bethesda, Maryland. As part of this exam, your doctor may do the following: Your doctor may order blood tests and imaging tests to help diagnose pulmonary hypertension. Learn more about participating in a clinical trial. This study is exploring how a medicine called an oral nitrate gets broken down in healthy adults, compared with how it breaks down in those who have pulmonary hypertension with normal pump function of their heart, also known as heart failure with preserved ejection fraction (PH-HFpEF). Look for swelling in your abdomen and legs that may be caused by fluid buildup. Medical conditions that can cause pulmonary hypertension include: You may have an increased risk for pulmonary hypertension because of your age, environment, family history and genetics, lifestyle habits, medicines you are taking, other medical conditions, or sex. 2013;369(4):319-29. This study is located in Bethesda, Maryland. Researchers who study cardiovascular health have long known that exercise is one way to keep high blood pressure at bay. These other tests can help diagnose pulmonary hypertension. This means that the blood vessels that carry blood from the heart to the lungs become hard and narrow, making the heart work harder to pump the blood through. Listen to your lungs for sounds that could be caused by heart failure or interstitial lung disease. Learn about the following ways the NHLBI continues to translate current research into improved health for people with pulmonary hypertension. This study is located in St. Louis, Missouri. To help prevent pulmonary hypertension, your doctor may recommend controlling certain medical conditions, avoiding certain medicines or illegal drugs, and protecting yourself against environmental hazards that are risk factors. To understand pulmonary hypertension, it is helpful to understand the flow of blood through the heart and lungs. Pulmonary hypertension (PH) is high blood pressure in the arteries to your lungs. Pulmonary arterial hypertension, or PAH, is a type of high blood pressure that affects the arteries in your lungs and the right side of your heart. As we enter 2021, the Pulmonary Hypertension Association (PHA) welcomes important milestones and new beginnings. It results when the arteries carrying blood from the right side of the heart to the lungs are constricted, disrupting blood flow. Your doctor may recommend the following to monitor your condition and treatment response: If your pulmonary hypertension is severe or does not respond to treatment, your doctor may talk to you about a lung transplant or a heart and lung transplant. Normal pressure in the pulmonary arteries is between 11 and 20 millimeters of mercury (mm Hg) when measured by cardiac catheterization. Ghofrani HA, D'armini AM, Grimminger F, et al. Your risk of pulmonary hypertension goes up as you get older, although it may occur at any age. myPHteam is the social network for those living with pulmonary hypertension. Medicines to treat pulmonary hypertension may include: Your doctor may recommend a procedure, surgery, or therapy to treat pulmonary hypertension. Certain medical conditions can damage, change, or block the blood vessels of the pulmonary arteries. Centers for Disease Control and Prevention. One type of pulmonary hypertension—called pulmonary arterial hypertension—is caused by conditions that result in narrowing of the pulmonary arteries themselves, such as scleroderma or HIV. Onset is typically gradual. Know the signs and symptoms of pulmonary hypertension and how to recognize the possible complications. Advertising on our site helps support our mission. If left untreated, PH can lead to right heart failure and death. This study is located in Pittsburgh, Pennsylvania. 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